116 research outputs found

    Theoretical investigation of the thermal performance of a novel solar loop-heat-pipe façade-based heat pump water heating system

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    The aim of the paper was to present a dedicated theoretical investigation into the thermal performance of a novel solar loop-heat-pipe façade based heat pump water heating system. This involved thermo-fluid analyses, computer numerical model development, the model running up, modelling result analyses and conclusion. An energy balance network was established on each part and the whole range of the system to address the associated energy conversion and transfer processes. On basis of this, a computer numerical model was developed and run up to predict the thermal performance of such a system at different system configurations, layouts and operational conditions. It was suggested that the loop heat pipes could be filled with either water, R134a, R22 or R600a; of which R600a is the favourite working fluid owing to its relatively larger heat transfer capacity and positive pressure in operation. Variations in the system configuration, i.e., glazing covers, heat exchangers, would lead to identifiable differences in the thermal performance of the system, represented by the thermal efficiency and COP. Furthermore, impact of the external operational parameters, i.e., solar radiation and ambient air temperature, to the system's thermal performance was also investigated. The research was based on an innovative loop-heat-pipe façade and came up with useful results reflecting the thermal performance of the combined system between the façade and heat pump. This would help promote development and market penetration of such an innovative solar heating technology, and thus contribute to achieving the global targets in energy saving and carbon emission reduction

    Design and Control of the "TransBoat": A Transformable Unmanned Surface Vehicle for Overwater Construction

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    This paper presents the TransBoat, a novel omnidirectional unmanned surface vehicle (USV) with a magnetbased docking system for overwater construction with wave disturbances. This is the first such USV that can build overwater structures by transporting modules. The TransBoat incorporates two features designed to reject wave disturbances. First, the TransBoat's expandable body structure can actively transform from a mono-hull into a multi-hull for stabilization in turbulent environments by extending its four outrigger hulls. Second, a real-time nonlinear model predictive control (NMPC) scheme is proposed for all shapes of the TransBoat to enhance its maneuverability and resist disturbance to its movement, based on a nonlinear dynamic model. An experimental approach is proposed to identify the parameters of the dynamic model, and a subsequent trajectory tracking test validates the dynamics, NMPC controller and system mobility. Further, docking experiments identify improved performance in the expanded form of the TransBoat compared with the contracted form, including an increased success rate (of ~ 10%) and reduced docking time (of ~ 40 s on average). Finally, a bridge construction test verifies our system design and the NMPC control method

    Designer Lipid-Like Peptides: A Class of Detergents for Studying Functional Olfactory Receptors Using Commercial Cell-Free Systems

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    A crucial bottleneck in membrane protein studies, particularly G-protein coupled receptors, is the notorious difficulty of finding an optimal detergent that can solubilize them and maintain their stability and function. Here we report rapid production of 12 unique mammalian olfactory receptors using short designer lipid-like peptides as detergents. The peptides were able to solubilize and stabilize each receptor. Circular dichroism showed that the purified olfactory receptors had alpha-helical secondary structures. Microscale thermophoresis suggested that the receptors were functional and bound their odorants. Blot intensity measurements indicated that milligram quantities of each olfactory receptor could be produced with at least one peptide detergent. The peptide detergents' capability was comparable to that of the detergent Brij-35. The ability of 10 peptide detergents to functionally solubilize 12 olfactory receptors demonstrates their usefulness as a new class of detergents for olfactory receptors, and possibly other G-protein coupled receptors and membrane proteins.United States. Defense Advanced Research Projects Agency (DARPA-HR0011-09-C-0012)Massachusetts Institute of Technology. Undergraduate Research Opportunities Progra

    Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

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    Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes. Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18–85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR)25–75 mL/min per 1·73 m 2 of body surface area, and a urine albumin-to-creatinine ratio (UACR)of 300–5000 mg/g who had received maximum labelled or tolerated renin–angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0·75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders)were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0·75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for ≥30 days)or end-stage kidney disease (eGFR <15 mL/min per 1·73 m 2 sustained for ≥90 days, chronic dialysis for ≥90 days, kidney transplantation, or death from kidney failure)in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials.gov, number NCT01858532. Findings: Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325)or placebo group (n=1323). Median follow-up was 2·2 years (IQR 1·4–2·9). 79 (6·0%)of 1325 patients in the atrasentan group and 105 (7·9%)of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR]0·65 [95% CI 0·49–0·88]; p=0·0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3·5%)of 1325 patients in the atrasentan group and 34 (2·6%)of 1323 patients in the placebo group (HR 1·33 [95% CI 0·85–2·07]; p=0·208). 58 (4·4%)patients in the atrasentan group and 52 (3·9%)in the placebo group died (HR 1·09 [95% CI 0·75–1·59]; p=0·65). Interpretation: Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Funding: AbbVie

    Thoughts on the Model of Nonstock Enterprises

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    With consumption funds going out of control, people naturally turn their attention from the macro economy to the micro economy and set their eyes on the behavior of the enterprises. Transforming enterprises into joint-stock companies is a hypothetically logical solution to the problem of nonrepresentation of the long-term interests of enterprises.

    Thoughts on Not Establishing a Stockholding System for Enterprises

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    The loss of control over consumption funds [in society] has compelled people, naturally, to turn their attention from macro to micro problems, and to the question of the enterprises' behavior. The idea of converting the enterprises' capitalization to a stockholding system is a logical assumption with regard to the desire to resolve the problem that there is no one representing the long-term interests of the enterprises.

    Numerical Study on Thermal Management of Air-Cooling Model for Diamond, Triangular and Rectangular Lithium-Ion Batteries of Electric Vehicles

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    To improve the safety of electric vehicles, this paper analyzes the way of cooling lithium-ion batteries of electric vehicles and proposes an air-cooling scheme. First, a heat-generation model for the lithium-ion battery is prepared for numerical simulation and a finned air-cooling model is designed, which combines cold air with fins to lower the temperature of lithium-ion batteries. Through feasibility analysis, it is proved that the heat-generation model can reflect the actual heat generation of lithium-ion batteries. The cooling effect of the finned air-cooling model is also evaluated. The temperature can be 23.6 &deg;C lower than the maximum compared with lithium-ion batteries without cooling. The cooling effect is desirable for diamond, triangle and rectangular lithium-ion battery packs, among which the rectangular battery pack achieves the most desirable effect. To conclude, to ensure the safe operation of lithium-ion batteries in electric vehicles, air cooling can be used to control their temperature, with the cooling effect in the rectangular lithium-ion battery pack being the most desirable
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